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Understanding Mitotane: Uses, Mechanism, and Considerations
Mitotane is a specialized medication primarily used in the treatment of adrenal cortical carcinoma, a rare type of cancer affecting the adrenal glands. Unlike standard chemotherapy agents, Mitotane has a unique mechanism of action that targets adrenal cells specifically, reducing the production of certain steroid hormones and helping to control tumor growth. It is considered both an adrenolytic and cytotoxic agent, meaning it can destroy adrenal tissue while also exerting direct anti-cancer effects.
The administration of Mitotane is typically oral, with tablets that need to be taken several times daily. Because of its slow onset and prolonged half-life, careful monitoring of blood levels is crucial to ensure the drug remains within a therapeutic range. Physicians often start patients on lower doses, gradually increasing the amount to minimize side effects while maximizing effectiveness. Regular blood tests help track hormone levels, liver function, and the concentration…